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Largest body of clinical evidence in PNS

More data means more informed decisions. The SPRINT® PNS System provides clinically proven pain relief supported by the largest body of clinical evidence in PNS.

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20+

Published or ongoing prospective clinical studies1-18

100+

Peer-reviewed publications

$40M

DoD and NIH funding to support research

Gilmore 2025: 4-Year Follow Up After 60-day PNS in Low Back Pain

This long-term follow-up survey explored outcomes with SPRINT PNS in chronic LBP more than 4 years after treatment. SPRINT PNS can provide durable outcomes and intervention avoidance in follow-up.

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Gilmore 2025: 4-Year Follow Up After 60-day PNS in Low Back Pain Featured Image Gilmore 2025: 4-Year Follow Up After 60-day PNS in Low Back Pain Featured Image

Pritzlaff 2024: Review of Studies on PNS for Chronic Pain

This review summarizes findings from 10 prospective studies of PNS for chronic pain. Across all pain types included, patients reported substantial reductions in pain and/or pain interference with PNS.

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Graph of results Graph of results

Goree 2024: RCT of 60-Day PNS for Post-surgical TKA Pain

This double-blinded, placebo-controlled RCT demonstrated significant pain relief and improved function with PNS for postoperative knee pain at the end of treatment (EOT) and 1-month after EOT.

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RCT

Randomized controlled trials (RCTs)

Backed by 7 successful RCTs, more than any other PNS System

SPRINT PNS is supported by clinical data from 7 successful RCTs, which have demonstrated clinically significant improvements in pain, functional outcomes, medication usage, and/or quality of life across a variety of pain conditions, such as: 

  • Shoulder Pain3, 5
  • Post-Amputation Pain12, 15
  • Post-Surgical Pain 14, 17
  • Low Back Pain19
70% graphic

Real-world evidence

Backed by the largest review of real-world PNS data.

The largest retrospective review of real-word PNS data of over 6,100 patients, with over 71% demonstrating significant pain relief and/or improvement in quality of life following 60-day percutaneous PNS treatment with the SPRINT PNS System.20* 

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*The total rate of medical events collected from the product complaint database was approximately 6%, with skin irritation due to adhesive components as the most reported event. 

References

  1. Yu D, et al. Arch Phys Med Rehabil. 2001; 82(1): 20-25.
  2. Renzenbrink G, et al. Clin Rehabil. 2004; 18(4): 359-365.
  3. Chae J, et al. Am J Phys Med Rehabil. 2005; 84(11): 832-842.
  4. Chae J, et al. Pain Pract. 2013; 13(1): 59-67.
  5. Wilson R, et al. Am J Phys Med Rehabil. 2014; 93(1): 17-28.
  6. Wilson R, et al. Neuromodulation. 2014; 17(8): 771-776.
  7. Rauck R, et al. Neuromodulation. 2014; 17(2): 188-197.
  8. Ilfeld B, et al. Pain Pract. 2017; 17(7): 892-901.
  9. Ilfeld B, et al. J Orthop Surg Res. 2017; 12(1): 4.
  10. Wilson R, et al. Neuromodulation. 2018; 21(3): 290-295.
  11. Ilfeld B, et al. Neuromodulation. 2019; 22(5): 653-660.
  12. Gilmore C, et al. Neuromodulation. 2019; 22(5): 615-620.
  13. Gilmore C, et al. Reg Anesth Pain Med. 2020; 45(1): 44-51.
  14. Ilfeld B, et al. Anesthesiology. 2021; 135: 95–110.
  15. Albright-Trainer B, et al. Pain Mgmt. 2022; 12(3): 357-369.
  16. Gilmore C, et al. Interv Pain Med. 2023; 2(2): 100243.
  17. Goree J, et al. Neuromodulation. 2024; 27(5): 47-861.
  18. Ongoing studies listed on ClinicalTrials.gov as of January 21, 2025.
  19. McCormick Z, et al. Poster from NANS Annual Meeting 2025.
  20. Huntoon M, et al. Pain Physician. 2023; 26: 273-281.