Skip to main content
Clinical Trials
Menu
SPR
Healthcare Professionals
SPRINT® PNS System
Overview
Product Details
Clinical Evidence
Video Resources
Reimbursement
Education
Safety Information
MRI Safety Information
Patients & Caregivers
SPRINT® PNS System
Why SPRINT?
How It Works
What To Expect
Helpful FAQs
Safety Information
MRI Safety Information
Resources
Overview
Instructional Videos
Patient Stories
Recursos para pacientes
Clinical Evidence
About Us
About SPR
Leadership
Company Credo
News
Events
Careers
Overview
Job Listing
Contact Us
Search
Search
Explore more
Breadcrumb
Home
SPRINT PNS System
Clinical Evidence
Explore More
Explore the clinical evidence
View evidence archive
Pain Area
- All -
Head
Intercostal
Knee
Low back
Lower extremity
Multiple
Neck
Shoulder
▼
Toggle Options
Publication Type
- All -
Case reports
Clinical studies
Poster
Real-world data
Reviews & other publications
▼
Toggle Options
Search
Filter
Clinical studies
View All
Goree 2024: RCT of 60-Day PNS for Post-surgical TKA Pain
Summary
Multicenter RCT: 52 patients (41 in primary endpoint), 60-day PNS vs. sham for post-TKA pain.
Significant Primary Endpoint (≥50% pain relief at EOT): PNS, 60%,vs. Sham, 24% (p=0.028).
Significant improvements in function (walking distance), WOMAC, and PGIC QoL with PNS at EOT.
Gilmore 2023: Durable (14 months) relief of LBP with 60-Day PNS
Summary
Prospective, multicenter clinical trial of 60-Day PNS of lumbar medial branches for chronic LBP.
Clinically meaningful improvements sustained in majority of patients (77%) at 14-month follow-up.
60-Day PNS is a safe, effective 1st-line PNS treatment for recalcitrant CLBP.
Vangeison 2023: 60-Day PNS in Chronic OA Knee Pain Case Series
Summary
Retrospective review of 60-Day PNS treatment for nonsurgical chronic osteoarthritic knee pain (n=19)
Patients demonstrated improvement in their knee pain from baseline post-temporary PNS explant
Temporary PNS may be a treatment for patients with pain who can’t get surgery
Real-world data
View All
Valimahomed 2024: RWE of PNS for Chronic Shoulder Pain
Summary
Retrospective Real World Evidence (RWE) analysis of 768 patients with chronic shoulder pain.
Common PNS lead targets included the suprascapular and/or axillary nerves.
Improvements in multiple health domains (e.g., quality of life, physicial function, sleep) at EOT.
Gutierrez 2024: Chart Review of PNS for Chronic Shoulder Pain
Summary
Anonymized medical records were reviewed of patients who received SPRINT PNS for shoulder pain.
Over 80% of patients reported a substantial (≥50%) reduction in shoulder pain with SPRINT at EOT.
Bimodal stimulation produced the greatest percent pain relief.
Huntoon 2023: RWD Outcomes with PNS in Chronic Pain
Summary
Anonymized records of 6,160 patients implanted with SPRINT PNS were retrospectively reviewed
71% were responders with ≥50% pain relief and/or improvement in quality of life at end of treatment
Average and worst pain, percentage pain relief, and global impression of change were also reported
Reviews & other publications
View All
Pritzlaff 2024: Review of Studies on PNS for Chronic Pain
Summary
Ten studies were identified that prospectively studied PNS for treatment of chronic pain.
The studies included patients with shoulder pain, neuropathic pain, or low back pain.
Reductions in pain and/or pain interference were consistently reported across all pain types.
Deer 2021: Proposed Mechanism of Action for Percutaneous PNS
Summary
Discusses potential mechanisms by which PNS may provide prolonged reductions in pain.
Remote selective targeting with PNS may produce robust comfortable sensations in the area of pain.
Prolonged pain relief may occur as a reversal of maladaptive cortical plasticity driven by PNS.
Staats 2021: Surveys of Patient Preference for LBP Interventions
Summary
Study using two market research surveys of chronic pain patient preferences for LBP interventions.
LBP patients preferred temporary interventions to permanently implanted devices.
Temporary PNS was the most preferred treatment option over RFA and permanent implants.
Case reports
View All
Gutierrez 2024: PNS for CRPS Case Reports
Summary
SPRINT PNS was used to treat complex regional pain syndrome (CRPS).
Three cases of CRPS in the lower extremity with significant and sustained relief of pain.
These three cases suggest that 60-day PNS can be a safe and efficacious treatment for CRPS.
Kelly 2023: PNS Retrospective Case Series in Chronic Knee Pain
Summary
Retrospective case series (n=14): PNS targeting femoral and saphenous nerves for chronic knee pain
75% reported ≥50% pain reduction; 52% average pain relief at six months post-implantation
Demonstrated safety and efficacy with no adverse events
Mach 2023: Case series of lumbar PNS for cancer-related back pain
Summary
PNS for pain secondary to myeloma-related spinal lesions enabled pain relief for radiation therapy
Lumbar medial branch PNS is a promising option for back pain from primary or metastatic tumors
Four patients successfully used lumbar PNS for pain relief, allowing them to complete radiation
Posters
View All
McCormick 2025 NANS: RESET RCT Primary Endpoint Results in CLBP
Shaw 2025 NANS: EMR and Manufacturer Database Consistency
Aman 2025 NANS: Multicenter Review of Bimodal PNS in Shoulder