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Clinical Evidence Search

Huntoon 2023: RWD Outcomes with PNS in Chronic Pain
Summary
  • Anonymized records of 6,160 patients implanted with SPRINT PNS were retrospectively reviewed
  • 71% were responders with ≥50% pain relief and/or improvement in quality of life at end of treatment
  • Average and worst pain, percentage pain relief, and global impression of change were also reported
Vangeison 2023: 60-Day PNS in Chronic OA Knee Pain Case Series
Summary
  • Retrospective review of 60-Day PNS treatment for nonsurgical chronic osteoarthritic knee pain (n=19)
  • Patients demonstrated improvement in their knee pain from baseline post-temporary PNS explant
  • Temporary PNS may be a treatment for patients with pain who can’t get surgery
Moman 2021: PNS for Refractory Occipital Neuralgia (Case Report)
Summary
  • Single patient case report of temporary PNS (GON) followed by permanent PNS for occipital neuralgia
  • Temporary PNS provided resolution of pain and discontinuation of opioids during treatment of ON
  • Pain returned after removal. A permanent lead was implanted and provided relief for 12 months
Fiala 2022: Case Series of Lumbar Level PNS for Low Back Pain
Summary
  • Six reports of PNS targeting the lumbar medial branches for low back pain.
  • Patients reported an average 65% pain reduction with PNS.
  • Medial branch PNS may provide pain relief and functional improvements to those with refractory CLBP.
Pingree 2022: Long-Term Follow-Up Survey Following 60-Day PNS
Summary
  • Cross-sectional follow-up survey of SPRINT PNS patients.
  • Most patients reported meaningful pain relief and/or improvement in quality of life at follow up.
  • About one third of survey respondents also reported reducing or stopping medication use.
Naidu 2022: Real-World Analysis of Delayed Response to PNS
Summary
  • 60-day PNS treatment can help identify delayed responders and non-responders to stimulation
  • 38% of patients (n=747) were either delayed responders (31%) or delayed non-responders (7%)
  • 60-day PNS may help inform treatment strategies to optimize outcomes and cost for patients
Chitneni 2022: Case Reports of PNS in Rotator Cuff Pathology
Summary
  • Two reports of suprascapular & axillary nerve PNS for chronic shoulder pain after rotator cuff tear
  • Reported 80-90% pain relief and 50%-75% opioid reduction 3-months after completing 60-day PNS
  • 60-day PNS may provide sustained relief of rotator cuff pain recalcitrant to conservative treatments
Gilmore 2021: Multicenter Study of PNS in Chronic Low Back Pain
Summary
  • Prospective, multicenter study of percutaneous medial branch PNS for chroic axial low back pain
  • Majority of participants reported significant reductions in pain, disability, and pain interference
  • Percutaneous PNS offers a minimally invasive, promising first-line treatment for chronic axial LBP