Clinical Evidence Search | SPR

Clinical Evidence Search

Gilmore 2023: Durable (14 months) relief of LBP with 60-Day PNS

Summary

Prospective, multicenter clinical trial of 60-Day PNS of lumbar medial branches for chronic LBP.
Clinically meaningful improvements sustained in majority of patients (77%) at 14-month follow-up.
60-Day PNS is a safe, effective 1st-line PNS treatment for recalcitrant CLBP.

Moman 2021: PNS for Refractory Occipital Neuralgia (Case Report)

Summary

Single patient case report of temporary PNS (GON) followed by permanent PNS for occipital neuralgia
Temporary PNS provided resolution of pain and discontinuation of opioids during treatment of ON
Pain returned after removal. A permanent lead was implanted and provided relief for 12 months

Chitneni 2022: Case Reports of PNS in Rotator Cuff Pathology

Summary

Two reports of suprascapular & axillary nerve PNS for chronic shoulder pain after rotator cuff tear
Reported 80-90% pain relief and 50%-75% opioid reduction 3-months after completing 60-day PNS
60-day PNS may provide sustained relief of rotator cuff pain recalcitrant to conservative treatments

Naidu 2022: Real-World Analysis of Delayed Response to PNS

Summary

60-day PNS treatment can help identify delayed responders and non-responders to stimulation
38% of patients (n=747) were either delayed responders (31%) or delayed non-responders (7%)
60-day PNS may help inform treatment strategies to optimize outcomes and cost for patients

Shah 2022 ASRA: 60-Day PNS in Shoulder Pain RWD

Pingree 2022: Long-Term Follow-Up Survey Following 60-Day PNS

Summary

Cross-sectional follow-up survey of SPRINT PNS patients.
Most patients reported meaningful pain relief and/or improvement in quality of life at follow up.
About one third of survey respondents also reported reducing or stopping medication use.

Fiala 2022: Case Series of Lumbar Level PNS for Low Back Pain

Summary

Six reports of PNS targeting the lumbar medial branches for low back pain.
Patients reported an average 65% pain reduction with PNS.
Medial branch PNS may provide pain relief and functional improvements to those with refractory CLBP.

Woodbury 2021: Cervical PNS for Occipital Neuralgia Case Report

Summary

Novel percutaneous PNS approach targeting C2-3 medial branches for occipital neuralgia
Case report of patient with 80% headache pain reduction after 8 weeks of PNS treatment
Longitudinal C2-3 approach is less technically challenging than the traditional C1 transverse method

Deer 2021: Percutaneous PNS in Back Pain after Lumbar RFA

Summary

Prospective multicenter substudy exploring use of PNS as treatment for chronic back pain after RFA
Majority had clinically significant improvements in pain (≥50%) or functional outcomes, n=15
5 months after start of PNS, 93% reported clinically meaningful improvement in one or more outcomes

Ilfeld 2021: RCT of PNS in Acute Postoperative Pain

Summary

Secondary analysis of pilot RCT: brachial plexus and sciatic nerve PNS
PNS reduced postoperative pain, pain interference, and opioids in the first week after surgery
PNS for acute pain following orthopedic surgery is effective and free of systemic side effects

Gilmore 2021: Multicenter Study of PNS in Chronic Low Back Pain

Summary

Prospective, multicenter study of percutaneous medial branch PNS for chroic axial low back pain
Majority of participants reported significant reductions in pain, disability, and pain interference
Percutaneous PNS offers a minimally invasive, promising first-line treatment for chronic axial LBP

Albright-Trainer 2021: PNS vs SMT in Acute Post-Amputation Pain

Summary

RCT compared PNS vs standard medical therapy (SMT) in postoperative period following amputation
Greater reductions in pain and opioid use with PNS vs standard care for post-amputation pain (n=16)
PNS of sciatic and femoral nerves reduced opioid use and and postsurgical pain at 3 months