Clinical Evidence Search | SPR

Clinical Evidence Search

Staats 2021: Surveys of Patient Preference for LBP Interventions

Summary

Study using two market research surveys of chronic pain patient preferences for LBP interventions.
LBP patients preferred temporary interventions to permanently implanted devices.
Temporary PNS was the most preferred treatment option over RFA and permanent implants.

Ilfeld 2021: Pilot RCT of PNS for Postoperative Pain

Summary

Multicenter RCT: 66 patients randomized to active PNS vs. sham.
PNS was significantly lower vs sham (p<0.001) in the first 7 days after surgery.
Interference of pain with emotional and physical functioning was reduced with PNS.

Shaw 2021: PNS for Post-thoracotomy Intercostal Pain Case Reports

Summary

Two reports of durable relief (13-14 months) following 60-day PNS of intercostal nerves.
60-Day PNS of intercostal nerves for chronic post-thoractomy intercostal neuralgia.
PNS may reduce opioid and nonopioid medication usage in intercostal neuralgia pain.

Deer 2021: Proposed Mechanism of Action for Percutaneous PNS

Summary

Discusses potential mechanisms by which PNS may provide prolonged reductions in pain.
Remote selective targeting with PNS may produce robust comfortable sensations in the area of pain.
Prolonged pain relief may occur as a reversal of maladaptive cortical plasticity driven by PNS.

Gupta 2020: Cadaveric Feasibility of Intercostal PNS Implantation

Summary

Cadaveric study assessing ultrasound-guided intercostal PNS implantation
12 stimulators implanted between 5th and 10th ribs bilaterally between intercostal muscles
Average lead-to-nerve distance: 2.3 mm (SPR MicroLead) and 1.1 mm (StimRouter)

Mainkar 2020: Pilot Study in Termporary PNS in Oncologic Pain

Summary

Case series (n=12) demonstrates promising peripheral targets for the treatment of oncologic pain
Successful PNS targeting spinal nerves, brachial plexus, and peripheral nerves for oncological pain
Successful relief in 7 of 12 cases, with several reporting relief beyond lead removal

Gilmore 2020: PNS in Post-Amputation Pain RCT 12-mo Follow-Up

Summary

Placebo-controlled RCT of PNS for chronic neuropathic pain following lower extremity amputation
Majority had substantial reductions in pain 12 months after start of PNS, n=9
60-day PNS can provide significant long-term relief of chronic pain following amputation

Gilmore 2020: 1 Year Sustained Relief with PNS in Low Back Pain

Summary

Case series of Percutaneous PNS of Lumbar Medial Branches for axial back pain
Majority had clinically substantial (≥50%) pain relief at end of treatment compared to baseline, n=9
Majority had clinically significant pain and/or disability reductions at 12 months after PNS, n=6

Ilfeld 2019: Feasibility of PNS in Post-TKA Pain Management

Summary

Prospective study: 7 subjects, femoral and sciatic PNS for post-TKA pain
Pain scores <4/10 in 86% of subjects and 57% discontinued opioids during the first week
Functional recovery: average 6MWT improvement of 26% by 12 weeks; no device-related infections

Haider 2023: Case Report of Cervical PNS in Arthritic Neck Pain

Summary

Patient experienced 2 years of severe chronic pain following a work-related neck injury.
Physical therapy and over-the-counter pain medications did not provide sufficient relief.
PNS targeting the nerves of the cervical spine produced 50% reduction in pain at 2 months.

Gilmore 2019: Post-Amputation Pain RCT Primary Endpoint

Summary

RCT of PNS in chronic neuropathic pain following lower extremity amputation.
Significantly greater proportion with pain relief during PNS compared to placebo (sham) control.
Majority had substantial reductions in pain interference and improvements in function during PNS.

Wilson 2014: Single-arm study of PNS in Shoulder Pain from SIS

Summary

Studied PNS for refractory shoulder pain due to subacromial impingement syndrome
Significant reductions in pain and pain interference relative to baseline, n=10
Pain reduction is maintained for at least 12 weeks after treatment