Clinical Evidence Search | SPR

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Gilmore 2025: 4-Year Follow Up After 60-day PNS in Low Back Pain

Summary

Long-term follow-up survey for prior study shows outcomes in back pain 4 years after 60-day PNS
Majority of respondents reported sustained relief of back pain an average of 4.7 years after PNS
70% avoided progression to more costly, invasive, and/or destructive low back pain interventions

Goree 2024: RCT of 60-Day PNS for Post-surgical TKA Pain

Summary

Multicenter RCT: 52 patients (41 in primary endpoint), 60-day PNS vs. sham for post-TKA pain.
Significant Primary Endpoint (≥50% pain relief at EOT): PNS, 60%,vs. Sham, 24% (p=0.028).
Significant improvements in function (walking distance), WOMAC, and PGIC QoL with PNS at EOT.

Vangeison 2023: 60-Day PNS in Chronic OA Knee Pain Case Series

Summary

Retrospective review of 60-Day PNS treatment for nonsurgical chronic osteoarthritic knee pain (n=19)
Patients demonstrated improvement in their knee pain from baseline post-temporary PNS explant
Temporary PNS may be a treatment for patients with pain who can’t get surgery

Gilmore 2023: Durable (14 months) relief of LBP with 60-Day PNS

Summary

Prospective, multicenter clinical trial of 60-Day PNS of lumbar medial branches for chronic LBP.
Clinically meaningful improvements sustained in majority of patients (77%) at 14-month follow-up.
60-Day PNS is a safe, effective 1st-line PNS treatment for recalcitrant CLBP.

Ilfeld 2021: Pilot RCT of PNS for Postoperative Pain

Summary

Multicenter RCT: 66 patients randomized to active PNS vs. sham.
PNS was significantly lower vs sham (p<0.001) in the first 7 days after surgery.
Interference of pain with emotional and physical functioning was reduced with PNS.

Albright-Trainer 2021: PNS vs SMT in Acute Post-Amputation Pain

Summary

RCT compared PNS vs standard medical therapy (SMT) in postoperative period following amputation
Greater reductions in pain and opioid use with PNS vs standard care for post-amputation pain (n=16)
PNS of sciatic and femoral nerves reduced opioid use and and postsurgical pain at 3 months

Gilmore 2021: Multicenter Study of PNS in Chronic Low Back Pain

Summary

Prospective, multicenter study of percutaneous medial branch PNS for chroic axial low back pain
Majority of participants reported significant reductions in pain, disability, and pain interference
Percutaneous PNS offers a minimally invasive, promising first-line treatment for chronic axial LBP

Ilfeld 2021: RCT of PNS in Acute Postoperative Pain

Summary

Secondary analysis of pilot RCT: brachial plexus and sciatic nerve PNS
PNS reduced postoperative pain, pain interference, and opioids in the first week after surgery
PNS for acute pain following orthopedic surgery is effective and free of systemic side effects

Deer 2021: Percutaneous PNS in Back Pain after Lumbar RFA

Summary

Prospective multicenter substudy exploring use of PNS as treatment for chronic back pain after RFA
Majority had clinically significant improvements in pain (≥50%) or functional outcomes, n=15
5 months after start of PNS, 93% reported clinically meaningful improvement in one or more outcomes

Gilmore 2020: 1 Year Sustained Relief with PNS in Low Back Pain

Summary

Case series of Percutaneous PNS of Lumbar Medial Branches for axial back pain
Majority had clinically substantial (≥50%) pain relief at end of treatment compared to baseline, n=9
Majority had clinically significant pain and/or disability reductions at 12 months after PNS, n=6

Gilmore 2020: PNS in Post-Amputation Pain RCT 12-mo Follow-Up

Summary

Placebo-controlled RCT of PNS for chronic neuropathic pain following lower extremity amputation
Majority had substantial reductions in pain 12 months after start of PNS, n=9
60-day PNS can provide significant long-term relief of chronic pain following amputation

Ilfeld 2019: Feasibility of PNS in Post-TKA Pain Management

Summary

Prospective study: 7 subjects, femoral and sciatic PNS for post-TKA pain
Pain scores <4/10 in 86% of subjects and 57% discontinued opioids during the first week
Functional recovery: average 6MWT improvement of 26% by 12 weeks; no device-related infections