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Clinical Evidence Search

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Pritzlaff 2024: Review of Studies on PNS for Chronic Pain
Summary
  • Ten studies were identified that prospectively studied PNS for treatment of chronic pain.
  • The studies included patients with shoulder pain, neuropathic pain, or low back pain.
  • Reductions in pain and/or pain interference were consistently reported across all pain types.
Deer 2021: Proposed Mechanism of Action for Percutaneous PNS
Summary
  • Discusses potential mechanisms by which PNS may provide prolonged reductions in pain.
  • Remote selective targeting with PNS may produce robust comfortable sensations in the area of pain.
  • Prolonged pain relief may occur as a reversal of maladaptive cortical plasticity driven by PNS.
Staats 2021: Surveys of Patient Preference for LBP Interventions
Summary
  • Study using two market research surveys of chronic pain patient preferences for LBP interventions.
  • LBP patients preferred temporary interventions to permanently implanted devices.
  • Temporary PNS was the most preferred treatment option over RFA and permanent implants.
Gupta 2020: Cadaveric Feasibility of Intercostal PNS Implantation
Summary
  • Cadaveric study assessing ultrasound-guided intercostal PNS implantation
  • 12 stimulators implanted between 5th and 10th ribs bilaterally between intercostal muscles
  • Average lead-to-nerve distance: 2.3 mm (SPR MicroLead) and 1.1 mm (StimRouter)