Clinical Evidence Search | SPR

Clinical Evidence Search

Haider 2023: Case Report of Cervical PNS in Arthritic Neck Pain

Summary

Patient experienced 2 years of severe chronic pain following a work-related neck injury.
Physical therapy and over-the-counter pain medications did not provide sufficient relief.
PNS targeting the nerves of the cervical spine produced 50% reduction in pain at 2 months.

Gilmore 2019: Post-Amputation Pain RCT Primary Endpoint

Summary

RCT of PNS in chronic neuropathic pain following lower extremity amputation.
Significantly greater proportion with pain relief during PNS compared to placebo (sham) control.
Majority had substantial reductions in pain interference and improvements in function during PNS.

Ilfeld 2019: Feasibility of PNS in Post-TKA Pain Management

Summary

Prospective study: 7 subjects, femoral and sciatic PNS for post-TKA pain
Pain scores <4/10 in 86% of subjects and 57% discontinued opioids during the first week
Functional recovery: average 6MWT improvement of 26% by 12 weeks; no device-related infections

Wilson 2014: Single-arm study of PNS in Shoulder Pain from SIS

Summary

Studied PNS for refractory shoulder pain due to subacromial impingement syndrome
Significant reductions in pain and pain interference relative to baseline, n=10
Pain reduction is maintained for at least 12 weeks after treatment

Wilson 2014: PNS vs. Usual Care RCT in Hemiplegic Shoulder Pain

Summary

Randomized controlled trial of single-lead PNS for shoulder pain, n=25
Significantly greater reductions in pain for the PNS group compared to controls
Pain reduction was maintained for at least 12 weeks after treatment

Chae 2005: RCT with 12-month Follow-Up in Hemiplegic Shoulder

Summary

Randomized controlled trial comparing PNS and Standard of Care for Hemiplegic Shoulder Pain (n=61).
Blinded, multicenter RCT with durable, statistically significant relief with PNS through 12 months.
Significantly higher success rate for PNS vs. control through 12 months (p<0.05).

Yu 2001: Case Series of PNS for Shoulder Subluxation and Pain

Summary

Explored feasibility of treating shoulder subluxation and pain in patients with chronic hemiplegia
Case series of n=8 patients receiving 6 weeks of stimulation
Shoulder pain, subluxation, pain-free rotation, and disability improved significantly with PNS