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Clinical Evidence Search

Huntoon 2023: RWD Outcomes with PNS in Chronic Pain
Summary
  • Anonymized records of 6,160 patients implanted with SPRINT PNS were retrospectively reviewed
  • 71% were responders with ≥50% pain relief and/or improvement in quality of life at end of treatment
  • Average and worst pain, percentage pain relief, and global impression of change were also reported
Mach 2023: Case series of lumbar PNS for cancer-related back pain
Summary
  • PNS for pain secondary to myeloma-related spinal lesions enabled pain relief for radiation therapy
  • Lumbar medial branch PNS is a promising option for back pain from primary or metastatic tumors
  • Four patients successfully used lumbar PNS for pain relief, allowing them to complete radiation
Kelly 2023: PNS Retrospective Case Series in Chronic Knee Pain
Summary
  • Retrospective case series (n=14): PNS targeting femoral and saphenous nerves for chronic knee pain
  • 75% reported ≥50% pain reduction; 52% average pain relief at six months post-implantation
  • Demonstrated safety and efficacy with no adverse events
Gilmore 2023: Durable (14 months) relief of LBP with 60-Day PNS
Summary
  • Prospective, multicenter clinical trial of 60-Day PNS of lumbar medial branches for chronic LBP.
  • Clinically meaningful improvements sustained in majority of patients (77%) at 14-month follow-up.
  • 60-Day PNS is a safe, effective 1st-line PNS treatment for recalcitrant CLBP.
Moman 2021: PNS for Refractory Occipital Neuralgia (Case Report)
Summary
  • Single patient case report of temporary PNS (GON) followed by permanent PNS for occipital neuralgia
  • Temporary PNS provided resolution of pain and discontinuation of opioids during treatment of ON
  • Pain returned after removal. A permanent lead was implanted and provided relief for 12 months
Chitneni 2022: Case Reports of PNS in Rotator Cuff Pathology
Summary
  • Two reports of suprascapular & axillary nerve PNS for chronic shoulder pain after rotator cuff tear
  • Reported 80-90% pain relief and 50%-75% opioid reduction 3-months after completing 60-day PNS
  • 60-day PNS may provide sustained relief of rotator cuff pain recalcitrant to conservative treatments
Naidu 2022: Real-World Analysis of Delayed Response to PNS
Summary
  • 60-day PNS treatment can help identify delayed responders and non-responders to stimulation
  • 38% of patients (n=747) were either delayed responders (31%) or delayed non-responders (7%)
  • 60-day PNS may help inform treatment strategies to optimize outcomes and cost for patients