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Clinical Evidence Search

Goree 2024: RCT of 60-Day PNS for Post-surgical TKA Pain
Summary
  • Multicenter RCT: 52 patients (41 in primary endpoint), 60-day PNS vs. sham for post-TKA pain.
  • Significant Primary Endpoint (≥50% pain relief at EOT): PNS, 60%,vs. Sham, 24% (p=0.028).
  • Significant improvements in function (walking distance), WOMAC, and PGIC QoL with PNS at EOT.
Valimahomed 2024: RWE of PNS for Chronic Shoulder Pain
Summary
  • Retrospective Real World Evidence (RWE) analysis of 768 patients with chronic shoulder pain.
  • Common PNS lead targets included the suprascapular and/or axillary nerves.
  • Improvements in multiple health domains (e.g., quality of life, physicial function, sleep) at EOT.
Pritzlaff 2024: Review of Studies on PNS for Chronic Pain
Summary
  • Ten studies were identified that prospectively studied PNS for treatment of chronic pain.
  • The studies included patients with shoulder pain, neuropathic pain, or low back pain.
  • Reductions in pain and/or pain interference were consistently reported across all pain types.
Gutierrez 2024: PNS for CRPS Case Reports
Summary
  • SPRINT PNS was used to treat complex regional pain syndrome (CRPS).
  • Three cases of CRPS in the lower extremity with significant and sustained relief of pain.
  • These three cases suggest that 60-day PNS can be a safe and efficacious treatment for CRPS.
Gutierrez 2024: Chart Review of PNS for Chronic Shoulder Pain
Summary
  • Anonymized medical records were reviewed of patients who received SPRINT PNS for shoulder pain.
  • Over 80% of patients reported a substantial (≥50%) reduction in shoulder pain with SPRINT at EOT.
  • Bimodal stimulation produced the greatest percent pain relief.
Huntoon 2023: RWD Outcomes with PNS in Chronic Pain
Summary
  • Anonymized records of 6,160 patients implanted with SPRINT PNS were retrospectively reviewed
  • 71% were responders with ≥50% pain relief and/or improvement in quality of life at end of treatment
  • Average and worst pain, percentage pain relief, and global impression of change were also reported
Vangeison 2023: 60-Day PNS in Chronic OA Knee Pain Case Series
Summary
  • Retrospective review of 60-Day PNS treatment for nonsurgical chronic osteoarthritic knee pain (n=19)
  • Patients demonstrated improvement in their knee pain from baseline post-temporary PNS explant
  • Temporary PNS may be a treatment for patients with pain who can’t get surgery